Clinical outcomes, treatment patterns and health resource utilization (HRU) among metastatic breast cancer (mbc) patients (pts) with germline BRCA mutation (gBRCAm)

The Impacts of Inclusion in Clinical Trials on Outcomes among Patients with Metastatic Breast Cancer (MBC)

BACKGROUND Metastatic breast cancer (MBC) remains a devastating and incurable disease. Over the past decade, the implementation of clinical trials both with and without molecular targeted therapeutics has impacted the daily clinical treatment of patients with MBC. In this study, we determine whether including MBC patients in clinical trials affects clinical outcomes. METHODS We retrospectivel...

Management Of Metastatic Breast Cancer (MBC).

UNLABELLED Chemotherapy of metastatic breast carcinoma so far, is not curative using the currently available chemotherapeutic, hormonal or biologic agents. The treatment of metastatic breast cancer is aimed mainly at alleviation of symptoms rather than cure. The first choice of therapy is dependent on patient age, performance status, hormone receptor status, human epidermal growth factor recept...

Treatment Patterns and Outcomes in Elderly Patients with Metastatic Breast Cancer: A Multicenter Retrospective Study

Purpose Currently, there is little information regarding optimal treatment for metastatic breast cancer (MBC) in elderly patients. In this retrospective study, we examined a cohort of elderly patients with MBC receiving a range of treatments, in terms of demographic and clinicopathologic characteristics, treatment patterns, and outcomes. Methods Patients aged 65 years and older, and diagnosed...

Mutation Screening of BRCA Genes in 10 Iranian Males with Breast Cancer

Male breast cancer is a rare disease with an increasing trend. Due to limited information especially about the genetic basis of the disease in Iran and the lower age of its onset, the disease requires more attention. The aim of this study was to screen the male patients with breast cancer for BRCA mutations as well as tissue markers of estrogen receptor (ER), progesterone receptor (PR), human e...

Surgical Treatment of Breast Cancer in BRCA-Mutation Carriers.